个人简历 Resume

2012- 至今 清华大学生物医学工程系 Tenure track 助理教授

2012-2014 哈佛大学物理系 访问学者

2009-2012 清华大学生物医学工程系 副研究员

2006-2009 清华大学生物医学工程系 助理研究员

2001-2006 清华大学医学院 生物学博士

1996-2001 北京大学医学部 临床医学学士

2012-Present Tsinghua University, Tenure track Assistant Professor

2012-2014 Harvard University, Visiting Scholar 2009-2012 Tsinghua University, Associate Professor 2006-2009 Tsinghua University, Assistant Professor 2001-2006 Tsinghua University, Ph.D in Biology

1996-2001 Peking University Health Science Center, Bachelor in Clinical Medicine

研究领域与方向 Research Fields

我们致力于重大疾病的分子诊断研究，分子诊断是实现精准医学的重要途径。我们研究工作的特 点是综合运用多学科交叉的方法，来加深我们对于疾病早期诊断和个性化治疗的认识，并提供新 的临床诊断技术。

我们的研究工作已经惠及病人和社会，转换为分子诊断产品 2 项。这 2 项产品已获得中国医疗器 械批文和欧盟 CE 临床诊断证书，并荣获北京市自主创新产品等奖励。

The age of preventive, predictive and personalized (3P) medicine is coming. Two major drivers of 3P medicine are extracting the molecular fingerprints of each individuals and developing ultra-high sensitive and throughput technologies for measurement. By intimately integrating the interdisciplinary approaches of medicine, biology, and engineering, we are investigating omics repertoires from single cells and single individuals, developing new tools and discovering new biomarkers. The overarching goal is to improve the early diagnosis and personalized treatment of infectious diseases, inherited diseases and cancer.

We are actively involved in both basic and translational research. Two diagnostic products from our research have been certified by China FDA and European CE, and both were selected as National New Products and Beijing Independent Innovation Products.

代表性论文 Selected Publications

1. Tan X, Qin W, Zhang L, Hang J, Chen Z, Li B, Zhang C, Wan J, Zhou F, Shao K, Sun Y, Wu J, Zhang X, Qiu B, Li N, Shi S, Feng X, Zhao S, Wang Z, Zhao X, Yu Z, Mitchelson K, Cheng J, Guo Y# and He J#. A 5-microRNA Signature for Lung Squamous Cell Carcinoma Diagnosis and hsa-miR-31 for Prognosis. Clinical Cancer Research. 2011, 17(21):6802-6811.

2. Guo H, Liu H, Mitchelson K, Luo M, Sun Y, Xie L, Zhang L, Lu Y, Zhou Y, Guo Y# and Cheng J#. MicroRNAs-372/373 Promote the Expression of Hepatitis B Virus Through the Targeting of Nuclear Factor I/B. Hepatology, 2011, 54(3):808-819.

3. Zhu L, Jiang G, Wang S, Wang C, Li Q, Yu H, Zhou Y, Zhao B, Huang H, Xing W, Mitchelson K, Cheng J, Zhao Y# and Guo Y#. Biochip System for Rapid and Accurate Identification of Mycobacteria Species from Isolates and Sputum. Journal of Clinical Microbiology, 2010, 48(10):3654-3660.

4. Guo Y*, Zhou Y*, Wang C, Zhu L, Wang S, Li Q, Jiang G, Zhao B, Huang H, Yu H, Xing W, Mitchelson K, Cheng J and Zhao Y. Rapid, Accurate Determination of Multidrug Resistance in M. Tuberculosis Isolates and Sputum Using a Biochip System. International Journal of Tuberculosis and Lung Disease, 2009, 13(7): 914-920.

5. Guo Y*, Chen Z*, Zhang L, Zhou F, Shi S, Feng, X, Li, B, Meng, X, Ma, X, Luo M, Shao K, Li N, Qiu B, Mitchelson K, Cheng J. and He J. Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma. Cancer Research, 2008, 68(1): 26-33.

联系方式

+86-10-62783960

yongguo@tsinghua.edu.cn